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Honors
Distinguished Faculty Author, President and Provost, Howard
University 1998-2000; 200-2001; 2001-2002; 2002-2003; 2004-2005;
2005-2006, 2006-2007, 2007-2008, 2008-2009: Recognition and
Award by Howard University under Presidential Merit Superior
Performance Awards:2000-2001, 2002, 2003, 2004, 2006; 2007,
2008, 2009
B. Research Interests
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Biopharmaceutical Applications of Nanotechnology
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Controlled Drug Delivery and Drug Targeting
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Pharmacokinetics in Pharmaceutical Dosage Form Design
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Biopharmaceutics
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Pulsatile Drug Delivery Systems
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Biomaterials
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Drug Formulation and Stability Studies
C. Selected Peer-Reviewed Publications In Chronological Order
1. Patent : “Novel pHSensitive Hydrogels with
Adjustable Swelling Kinetics for Colon-Specific Delivery of
Peptides and Proteins” Patent Number:WO9801421 (Published on
01/15/1998). Inventors: Jindrich Kopecek, Pavla Kopeckova,
Emmanuel O. Akala, Ping-Yang Yeh, and Karel Ulbrich.
2. E. O. Akala, P. Kopeckova and J. Kopecek, Novel pH Sensitive
Hydrogels with Adjustable Kinetics of
Swelling. Biomaterials 19; 1037 - 1047(1998).
3. R. Groning, S. Weyel, E. Akala, E. Minkow and N. Lambow.
Computer-Controlled Release of Oxprenolol
from Capsules Using Gas Producing Cells and Electronic Circuits,
Pharmazie 54(7); 510-513 (1999).
4. W. Yin, E. Akala, and R. Taylor, Design of naltrexone-loaded
hydrolyzable crosslinked nanoparticles
International Journal of Pharmaceutics, 244(1-2); 9-19(2002)
5. Emmanuel O. Akala, Oluchi Elekwachi, Vantoria Chase,
Hausalynn Johnson, Marjorie Lazarre, Kenneth
Scott. “Organic redox-initiated polymerization process for the
fabrication of hydrogels for colon-specific drug delivery” Drug
Development Industrial Pharmacy, 29 (No 4);
375-386(2003)
6. Akala, E.O. “Oral Controlled Release Solid Dosage Forms” in
Theory and Practice of Contemporary
Pharmaceutics, Edited by Tapash K. Gosh and Bhaskara R Jasti (CRC
Press LLC, Boca Raton, FL). In Press (ISBN:
0415288630, March 1, 2004)
7. Gaofeng Pan, Yahia Lemmouchi, Oladapo Bakare and Emmanuel O.
Akala
Studies on
PEGylated and Drug-Loaded PAMAM Dendrimers
Journal of Bioactive and Compatible Polymers 20;113-128 (2005)
8. Emmanuel O. Akala, “Chapter 7.3: Effect of Packaging on
Stability of Drugs and Drug Products” in
Pharmaceutical Manufacturing Handbook: Regulations and
Stability (2008). Edited by Shayne Cox Gad.
Published by John Wiley & Sons, Inc. Hoboken, New Jersey. ISBN:
978-0-470-25959-7
9. E. O. Akala “Strategies
for Transmembrane Passage of Polymer-Based Nanostructures” in
Polymer-Based
Nanostructures: Medical Applications (A Book In The Series
“Nanoscience and Nanotechnology”) Published By The Royal
Society of Chemistry. The Book Series is Edited By Nobel
Laureate Professor Sir Harry Kroto from The University of
Sussex,
Professor Paul O'Brien from The University of Manchester and
Professor Harold Craighead from Cornell University (In Press)
10. E. Akala; H. Wang, R. Zhang; R. Taylor and A. Adedoyin
Disposition of Naltrexone after Intravenous Bolus Administration
in
Wistar Rats, Low Alcohol Drinking Rats and
High Alcohol Drinking Rats: Neuropsychobiology 2008;58:81-90
D. Research Support: Ongoing Support
(a) PI: Emmanuel O. Akala: NIH/National Cancer Institute:
“Biodegradable Polymeric Nanosphere Drug Delivery System For
Cancer Chemotherapy" (Grant #: 1 SC2 CA138179-01) 2008-2011
$333,000
(b) 1 C06 RR 020608-01 Lecca (PI)
09/30/2004-08/31/2009 NIH/NCRR ($3,519, 000)
Renovation of the First and Ground Floors in the School of
Pharmacy to House the Center for Drug Research and
Development.
To facilitate collaborative research efforts
in the areas of drug research and
development
Role: Co-PI (Emmanuel O. Akala)
(c) Howard University Fund for Academic Excellence Grants
Program, Cycle 14, Travel Grant Proposal Akala (PI) 07/01/ 2008-
06/30/2009
Visit to the Chao Center for Industrial Pharmacy and Workshop on
Statistical Experimental Design Role: PI
Completed Research Support
(a) 1 R21 AA13407 Akala (PI) 02/28/2002-08/30/2006 NIH/NIAAA
Controlled Drug Delivery System for Naltrexone: $450,000 (b) W.
M. Keck Foundation for Keck Center for the Design of
Nanoscale Materials for Molecular Recognition at Howard
University: $1,000,000 for Five Research Groups (Akala Co-PI)
01/02/2002 -12/31/2004
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